Cell & Gene Therapy: Bayer's Strategy

We are on the cusp of a new wave of innovation in healthcare 

For decades, many diseases have been labeled as “intractable”, meaning medicine could not provide an answer for patients beyond addressing their symptoms to a certain extent. By targeting diseases at the cellular or genetic level, we have the potential to shift from treating symptoms to stopping or even reversing diseases.

people

Heart failure, neurodegenerative diseases like

Parkinson’s
, or genetic diseases like
Huntington’s
are just a few examples of where
cell and gene therapies may make a difference
in the lives of patients.

A pharmaceutical (r)evolution: cell therapy and gene therapy 

Bayer’s journey began over 125 years ago with small molecule pharmaceuticals. Large molecules and targeted therapies came next. These treatments opened new doors and improved the lives of millions of patients. Researchers are already working on the next wave of innovation: cell therapy and gene therapy. These could be a breakthrough for patients living with diseases for which limited or no options are available today.

Three waves of innovation in the pharmaceuticals space:

Three waves of innovation in the pharmaceuticals space:
investment

Between 2019 and 2023, Bayer has invested more than

€ 3.5 billion
in the build-up of a
cell and gene therapy platform
. This includes the acquisition of
BlueRock
and
AskBio
, as well as a collaboration with
Mammoth Biosciences
.

Pioneering scientific advancement

We believe that a healthier future can be achieved by leveraging science, passion and collaboration. We are combining our internal expertise with external collaborations and acquisitions, jointly advancing the potential of the next wave of innovation in the pharmaceuticals space for the ultimate benefit of patients

BlueRock Therapeutics
2019

We ventured into iPSC (induced pluripotent stem cell) therapy acquiring BlueRock Therapeutics, a company founded by Leaps by Bayer.

AskBio
2020

We joined forces with Asklepios BioPharmaceutical (AskBio), a gene therapy leader with a rich pipeline and manufacturing capabilities.

Mammoth Biosciences
2022

We entered into a collaboration with Mammoth Biosciences, building gene editing capabilities to enable next-generation cell therapies, gene therapies and drive standalone therapeutic applications.

cell and gene therapies

Did you know that there are already multiple approved

cell therapies and gene therapies
for the treatment of various types of cancer, certain blood disorders like hemophilia A and B, as well as other rare diseases such as spinal muscular atrophy?

We are shifting treatment paradigms... 

First-generation cell and gene therapies are already impacting the lives of patients around the world. The future is enormously exciting – cell therapy and gene therapy could lead to far more targeted, personalized treatments. It could also mean finding a way to finally defeat diseases that we once thought untreatable.

... across multiple areas

heart failure
Heart Failure
Degenerative Diseases
Degenerative Diseases

(like Parkinson’s disease or some retinal disorders)

Genetic Diseases
Genetic Diseases

(such as Huntington’s disease or Limb-Girdle muscular dystrophy)


    References
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    • 1
      American Society of Gene and Cell Therapy, and Citeline. Gene, Cell, & RNA Therapy Landscape: Q3 2022 Quarterly Data Report, https://asgct.org/global/documents/asgct-citeline-q3-2022-report.aspx. Accessed Dec. 2022.
    • 2
      OCT) JX Yu et al., Nature vol 19, September 2020; AAV) Cortellis; GE) Cortellis; iPSC) JY Kim et al., Stem cell reviews and reports, Springer, September 2021